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| Registros recuperados : 22 | |
| 4. |  | BASTOS, A. P. A.; BARON, L. F.; TREVISOL, I. M.; IANISKI, F.; BRENTANO, L. Analysis of the cell immune response and of the renal morphological damage of Avian Infectious Bronchitis variants. In: ANNUAL CONGRESS OF THE BRAZILIAN SOCIETY OF IMMUNOLOGY, 43.; EXTRA SECTION OF CLINICAL IMMUNOLOGY, 6., 2018, Ouro Preto. Immuno 2018: abstract book. São Paulo: SBI, 2018.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 6. | | FONSECA, F. M. da; BARON, L. F.; TREVISOL, I. M.; BASTOS, A. P. A.; BRENTANO, L. Estudo de pré-formulação de nanovacina para tratamento da doença de newcastle em aves. In: WORKSHOP DE NANOTECNOLOGIA APLICADA AO AGRONEGÓCIO, 9., 2017, São Carlos, SP. Anais... São Carlos, SP: Embrapa Instrumentação, 2017. p. 235-238.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 7. | | BARON, L. F.; BASTOS, A. P. A.; BELLAVER, F. A. V.; FONSECA, F. M. da. Desenvolvimento, caracterização e avaliação da viabilidade celular de nanopartículas poliméricas contendo resveratrol. In: CONGRESSO INTERNACIONAL DE NANOTECNOLOGIA, 3.; SIMPÓSIO SOBRE NANOBIOTECNOLOGIA E SUAS APLICAÇÕES, 6., 2018, Novo Hamburgo. Trabalhos. Novo Hamburgo: Feevale, 2018. CINA 2018.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 9. | | BASTOS, A. P. A.; FONSECA, F. M. da; BARON, L. F.; PAESE, K. Nanotecnologia como ferramenta para manejo de coccidiose em frangos de corte. Avicultura Industrial, Itu, ed. 1321, ano 113, n. 07, p. 28-33, 2022. Avicultura Industrial, Itu, ed. 1321, ano 113, n. 7, p. 28-33, 2022.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 11. | | BARON, L. F.; FONSECA, F. M. da; BRENTANO, L.; TREVISOL, I. M.; SILVA, L. P. da; BASTOS, A. P. A. Desenvolvimento, caracterização e avaliação da citotoxicidade de virossoma para prevenção da doença de newcastle em aves. In: JORNADA DE INICIAÇÃO CIENTÍFICA, 12., 2018, Concórdia. Anais... Concórdia: Embrapa Suínos e Aves: UNC, 2018. p. 136-137.| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 12. | | BARON, L. F.; FONSECA, F. M. da; BRENTANO, L.; TREVISOL, I. M.; SILVA, L. P. da; BASTOS, A. P. A. Desenvolvimento, caracterização e avaliação da citotoxicidade de virossoma para prevenção da doença de newcastle em aves. In: JORNADA DE INICIAÇÃO CIENTÍFICA, 12., 2018, Concórdia. Anais... Concórdia: Embrapa Suínos e Aves: UNC, 2018. p. 136-137.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 13. | | BARON, L. F.; OSOWSKI, G. V.; VAZ, C. S. L.; RECH, D. V.; DUARTE, S. C.; BASTOS, A. P. A. Comparação da análise bacteriológica com a imuno-histoquímica para detecção de salmonella em tecidos de aves. In: JORNADA DE INICIAÇÃO CIENTÍFICA, 10., 2016, Concórdia. Anais... Concórdia: Embrapa Suínos e Aves: UNC, 2017. p. 103-105. JINC.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 14. | | BARON, L. F.; TREVISOL, I. M.; FONSECA, F. M. da; BRENTANO, L.; BELLAVER, F. A. V.; BASTOS, A. P. A. Comparação por diferentes métodos da resposta imune precoce induzida pela infecção com diferentes variantes de campo brasileiras do vírus da bronquite infecciosa em aves. In: JORNADA DE INICIAÇÃO CIENTÍFICA, 12., 2018, Concórdia. Anais... Concórdia: Embrapa Suínos e Aves: UNC, 2018. p. 66-67.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 15. | | TREVISOL, I. M.; MATTOS, G. L. M.; OKINO, C. H.; BRENTANO, L.; COLDEBELLA, A.; BARON, L. F.; BASTOS, A. P. A. Análise da resposta imune celular induzidas por desafio com amostras clássicas e variante de vírus da bronquite infecciosa aviária. CONFERÊNCIA FACTA-WPSA BRASIL, 2018, Campinas, SP. Avicultura 4.0: otimização dos processos de produção avícola. Campinas: FACTA, 2018. Prêmio Lamas 2018.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 16. | | FONSECA, F. M. da; BRENTANO, L.; BARON, L. F.; SILVA, L. P. da; SANTOS, M. S. C. dos; BASTOS, A. P. A. Different methods of cell viability analysis of cultures exposed to a nanovaccine for the prevention of newcastle disease in poultry. In: CONGRESSO BRASILEIRO DE VIROLOGIA, 29.; ENCONTRO DE VIROLOGIA DO MERCOSUL, 13., 2018, Gramado. Resumos... Brasília: SBV, 2018.| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 17. | | FONSECA, F. M. da; BRENTANO, L.; BARON, L. F.; SILVA, L. P. da; SANTOS, M. S. C. dos; BASTOS, A. P. A. Different methods of cell viability analysis of cultures exposed to a nanovaccine for the prevention of newcastle disease in poultry. In: CONGRESSO BRASILEIRO DE VIROLOGIA, 29.; ENCONTRO DE VIROLOGIA DO MERCOSUL, 13., 2018, Gramado. Resumos... Brasília: SBV, 2018.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 18. | | OSOWSKI, G. V.; BARON, L. F.; COLDEBELLA, A.; FONSECA, F. M. da; MOTA, S. C. A.; DEGENHARDT, R.; DUARTE, S. C. Comparative study of egg contamination with Salmonella Heidelberg and Salmonella Typhimurium. Brazilian Journal of Veterinary Research and Animal Science, v. 56, n. 1, el50479, 2019.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 19. | | MACIAG, S. S.; BELLAVER, F. A. V.; BOMBASSARO, G. E.; HAACH, V.; MORES, M. A. Z.; BARON, L. F.; COLDEBELLA, A.; BASTOS, A. P. A. On the influence of the source of porcine colostrum in the development of early immune ontogeny in piglets. Scientific Reports, v. 12, n. 15630, 2022.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 20. | | FONSECA, F. M. da; HAACH, V.; BELLAVER, F. V.; BOMBASSARO, G.; GAVA, D.; SILVA, L. P. da; BARON, L. F.; SIMONELLY, M.; CARVALHO, W. A.; SCHAEFER, R.; BASTOS, A. P. A. Immunological profile of mice immunized with a polyvalent virosome-based influenza vaccine. Virology Journal, v. 20, 2023. Article number 187. Na publicação: Francisco Noé Fonseca; Ana Paula Bastos.| Biblioteca(s): Embrapa Gado de Leite; Embrapa Recursos Genéticos e Biotecnologia; Embrapa Suínos e Aves. |
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| Registros recuperados : 22 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite; Embrapa Recursos Genéticos e Biotecnologia; Embrapa Suínos e Aves. |
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Data corrente: |
24/08/2023 |
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Data da última atualização: |
04/09/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 3 |
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Autoria: |
FONSECA, F. M. da; HAACH, V.; BELLAVER, F. V.; BOMBASSARO, G.; GAVA, D.; SILVA, L. P. da; BARON, L. F.; SIMONELLY, M.; CARVALHO, W. A.; SCHAEFER, R.; BASTOS, A. P. A. |
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Afiliação: |
FRANCISCO NOE DA FONSECA, GEM; VANESSA HAACH, Universidade Federal do Rio Grande do Sul; FRANCIANA VOLPATO BELLAVER, Instituto Federal Catarinense; GABRIELLY BOMBASSARO, Instituto Federal Catarinense; DANIELLE GAVA, CNPSA; LUCIANO PAULINO DA SILVA, Cenargen; LANA FLAVIA BARON, Universidade Federal do Rio Grande do Sul; MAYARA SIMONELLY, Universidade de Brasília; WANESSA ARAUJO CARVALHO, CNPGL; REJANE SCHAEFER, CNPSA; ANA PAULA ALMEIDA BASTOS, CNPSA. |
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Título: |
Immunological profile of mice immunized with a polyvalent virosome-based influenza vaccine. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Virology Journal, v. 20, 2023. Article number 187. |
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DOI: |
https://doi.org/10.1186/s12985-023-02158-0 |
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Idioma: |
Inglês |
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Notas: |
Na publicação: Francisco Noé Fonseca; Ana Paula Bastos. |
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Conteúdo: |
Abstract
Background: Influenza A virus (IAV) causes respiratory disease in pigs and is a major concern for public health.
Vaccination of pigs is the most successful measure to mitigate the impact of the disease in the herds. Influenza-based
virosome is an effective immunomodulating carrier that replicates the natural antigen presentation pathway and has
tolerability profile due to their purity and biocompatibility.
Methods: This study aimed to develop a polyvalent virosome influenza vaccine containing the hemagglutinin and
neuraminidase proteins derived from the swine IAVs (swIAVs) H1N1, H1N2 and H3N2 subtypes, and to investigate
its effectiveness in mice as a potential vaccine for swine. Mice were immunized with two vaccine doses (1 and 15
days), intramuscularly and intranasally. At 21 days and eight months later after the second vaccine dose, mice were
euthanized. The humoral and cellular immune responses in mice vaccinated intranasally or intramuscularly with a
polyvalent influenza virosomal vaccine were investigated.
Results: Only intramuscular vaccination induced high hemagglutination inhibition (HI) titers. Seroconversion
and seroprotection (>4-fold rise in HI antibody titers, reaching a titer of ?1:40) were achieved in 80% of mice
(intramuscularly vaccinated group) at 21 days after booster immunization. Virus-neutralizing antibody titers against
IAV were detected at 8 months after vaccination, indicating long-lasting immunity. Overall, mice immunized with the
virosome displayed greater ability for B, effector-T and memory-T cells from the spleen to respond to H1N1, H1N2 and
H3N2 antigens.
Conclusions: All findings showed an efficient immune response against IAVs in mice vaccinated with a polyvalent
virosome-based influenza vaccine. MenosAbstract
Background: Influenza A virus (IAV) causes respiratory disease in pigs and is a major concern for public health.
Vaccination of pigs is the most successful measure to mitigate the impact of the disease in the herds. Influenza-based
virosome is an effective immunomodulating carrier that replicates the natural antigen presentation pathway and has
tolerability profile due to their purity and biocompatibility.
Methods: This study aimed to develop a polyvalent virosome influenza vaccine containing the hemagglutinin and
neuraminidase proteins derived from the swine IAVs (swIAVs) H1N1, H1N2 and H3N2 subtypes, and to investigate
its effectiveness in mice as a potential vaccine for swine. Mice were immunized with two vaccine doses (1 and 15
days), intramuscularly and intranasally. At 21 days and eight months later after the second vaccine dose, mice were
euthanized. The humoral and cellular immune responses in mice vaccinated intranasally or intramuscularly with a
polyvalent influenza virosomal vaccine were investigated.
Results: Only intramuscular vaccination induced high hemagglutination inhibition (HI) titers. Seroconversion
and seroprotection (>4-fold rise in HI antibody titers, reaching a titer of ?1:40) were achieved in 80% of mice
(intramuscularly vaccinated group) at 21 days after booster immunization. Virus-neutralizing antibody titers against
IAV were detected at 8 months after vaccination, indicating long-lasting immunity. Overall, mice immunized with the
virosome... Mostrar Tudo |
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Palavras-Chave: |
Nanovaccine; Nanovacina; Nanovacinação; Seroprotection; Soro imunológico; Soro proteção; Soroproteção; Vaccine. |
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Thesagro: |
Influenza Aviaria; Vacina; Vacinação; Vírus. |
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Thesaurus NAL: |
Influenza A virus; Vaccination. |
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Categoria do assunto: |
--
X Pesquisa, Tecnologia e Engenharia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1156329/1/Immunological-profile-of-mice-immunized-with-a-polyvalent-virosome.pdf
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Marc: |
LEADER 03009naa a2200433 a 4500
001 2156179
005 2023-09-04
008 2023 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1186/s12985-023-02158-0$2DOI
100 1 $aFONSECA, F. M. da
245 $aImmunological profile of mice immunized with a polyvalent virosome-based influenza vaccine.$h[electronic resource]
260 $c2023
500 $aNa publicação: Francisco Noé Fonseca; Ana Paula Bastos.
520 $aAbstract Background: Influenza A virus (IAV) causes respiratory disease in pigs and is a major concern for public health. Vaccination of pigs is the most successful measure to mitigate the impact of the disease in the herds. Influenza-based virosome is an effective immunomodulating carrier that replicates the natural antigen presentation pathway and has tolerability profile due to their purity and biocompatibility. Methods: This study aimed to develop a polyvalent virosome influenza vaccine containing the hemagglutinin and neuraminidase proteins derived from the swine IAVs (swIAVs) H1N1, H1N2 and H3N2 subtypes, and to investigate its effectiveness in mice as a potential vaccine for swine. Mice were immunized with two vaccine doses (1 and 15 days), intramuscularly and intranasally. At 21 days and eight months later after the second vaccine dose, mice were euthanized. The humoral and cellular immune responses in mice vaccinated intranasally or intramuscularly with a polyvalent influenza virosomal vaccine were investigated. Results: Only intramuscular vaccination induced high hemagglutination inhibition (HI) titers. Seroconversion and seroprotection (>4-fold rise in HI antibody titers, reaching a titer of ?1:40) were achieved in 80% of mice (intramuscularly vaccinated group) at 21 days after booster immunization. Virus-neutralizing antibody titers against IAV were detected at 8 months after vaccination, indicating long-lasting immunity. Overall, mice immunized with the virosome displayed greater ability for B, effector-T and memory-T cells from the spleen to respond to H1N1, H1N2 and H3N2 antigens. Conclusions: All findings showed an efficient immune response against IAVs in mice vaccinated with a polyvalent virosome-based influenza vaccine.
650 $aInfluenza A virus
650 $aVaccination
650 $aInfluenza Aviaria
650 $aVacina
650 $aVacinação
650 $aVírus
653 $aNanovaccine
653 $aNanovacina
653 $aNanovacinação
653 $aSeroprotection
653 $aSoro imunológico
653 $aSoro proteção
653 $aSoroproteção
653 $aVaccine
700 1 $aHAACH, V.
700 1 $aBELLAVER, F. V.
700 1 $aBOMBASSARO, G.
700 1 $aGAVA, D.
700 1 $aSILVA, L. P. da
700 1 $aBARON, L. F.
700 1 $aSIMONELLY, M.
700 1 $aCARVALHO, W. A.
700 1 $aSCHAEFER, R.
700 1 $aBASTOS, A. P. A.
773 $tVirology Journal$gv. 20, 2023. Article number 187.
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Embrapa Suínos e Aves (CNPSA) |
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